2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N10411
    Morin 3-O-β-D-glucopyranoside 1169766-14-6 98%
    Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
    Morin 3-O-β-D-glucopyranoside
  • HY-N10452
    Methyl maslinate 22425-82-7 98%
    Methyl maslinate is a β-adrenergic antagonist. Methyl maslinate is a potent cardiotonic and antidysrhythmic agent. Methyl maslinate has the potential for hypertension research.
    Methyl maslinate
  • HY-N10593
    Ladanetin-6-O-β-D-glucopyranoside 89647-63-2 98%
    Ladanetin-6-O-β-D-glucopyranoside is an active flavonoid. Ladanetin-6-O-β-D-glucopyranoside has antioxidative effect. Ladanetin-6-O-β-D-glucopyranoside can be used for the research of cardioprotective effects.
    Ladanetin-6-O-β-D-glucopyranoside
  • HY-N10597
    5'''-O-Feruloyl complanatoside B 142473-98-1 98%
    5'''-O-Feruloyl complanatoside B is isolated from Astragali Semen, the seeds of Astragalus Complanatus. Semen Astragali Complanati (SAC) include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements; have been reported to involve in chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers.
    5'''-O-Feruloyl complanatoside B
  • HY-N10702
    PCSK9-IN-9 98%
    PCSK9-IN-9 is an isocoumarins of natural origin. PCSK9-IN-9 can inhibit proprotein convertase subtilisin-kexin type 9 (PCSK9), IDOL, and SREBP2 mRNA expression. PCSK9-IN-9 inhibits PCSK9 with an IC50 value of 11.9 μM.
    PCSK9-IN-9
  • HY-N10754
    Aschantin 13060-15-6 98%
    Aschantin, a bisepoxylignan, can be isolated from Magnolia biondii. Aschantin has antiplasmodial, Ca2+-antagonistic, platelet activating factor-antagonistic, and chemopreventive activities. Aschantin is a mTOR kinase inhibitor. Aschantin is also an inhibitor of Cytochrome P450 and UGT enzyme.
    Aschantin
  • HY-N10762
    15,16-Dihydrotanshindiol C 891854-96-9 98%
    15,16-Dihydrotanshindiol C, a diterpenoid, is a potent thrombin inhibitor.
    15,16-Dihydrotanshindiol C
  • HY-N10781
    Isograndifoliol 1445475-53-5 98%
    Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases.
    Isograndifoliol
  • HY-N10881
    Dihydrocurcumenone 142717-57-5 98%
    Dihydrocurcumenone is a carabrane-type sesquiterpene. Dihydrocurcumenone can be isolated from Curcuma zedoaria, and the common form is 4-dihydrocurcumenone. Curcuma zedoaria sesquiterpene has vascular relaxation activity. 4-dihydrocurcumenone can inhibit the high concentration of K+ induced constriction of isolated rat aortic strips.
    Dihydrocurcumenone
  • HY-N11076
    12E,14-Trien-19-oic acid 153042-80-9 98%
    12E,14-Trien-19-oic acid is a diterpenoid. 12E,14-Trien-19-oic acid can be isolated from Bhutanese medicinal plant, shug chher. 12E,14-Trien-19-oic acid can be used for the research of platelet aggregation.
    12E,14-Trien-19-oic acid
  • HY-N11081
    Hexanorcucurbitacin D 29065-05-2 98%
    Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD).
    Hexanorcucurbitacin D
  • HY-N11099
    (±)-Coclaurine 2033-08-1 98%
    (±)-Coclaurine is a natural product that can be found in Roemeria refracta. (±)-Coclaurine exhibits antioxidative activity and cardiovascular effects.
    (±)-Coclaurine
  • HY-N1156A
    α-Thevetin B 144300-21-0 98%
    α-Thevetin B（Compound 24） is a cardiac glycoside that can be isolated from Thevetia peruviana. α-Thevetin B（Compound 24） can be used in lung cancer, gastric cancer and pancreatic cancer research.
    α-Thevetin B
  • HY-N11690
    Oleandrigenin 465-15-6 98%
    Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na+/K+-ATP-ase inhibiting and cytotoxic activities.
    Oleandrigenin
  • HY-N12070
    11-O-β-D-glucopyranosyl thamnosmonin 952495-28-2 98%
    11-O-β-D-glucopyranosyl thamnosmonin, a coumarin glucosides, can be isolated from the roots of Angelica apaensis. 11-O-β-D-glucopyranosyl thamnosmonin has weak inhibitory activity on the aggregation of rabbit platelets induced by PAF, AA, and ADP.
    11-O-β-D-glucopyranosyl thamnosmonin
  • HY-N12528
    10,11-EDT 2763501-00-2 98%
    10,11-EDT, a soluble epoxide hydrolase (sEH) substrate, is a metabolic product of adrenic acid. 10,11-EDT is an endothelium-derived hyperpolarizing factor with strong vasorelaxant effects.
    10,11-EDT
  • HY-N12745
    3-Epigitoxigenin 465-10-1 98%
    3-Epigitoxigenin is a cardiac glycoside that can be isolated from the seeds of Strophanthus diuaricatus.
    3-Epigitoxigenin
  • HY-N13250
    Hawthorn Extract 98%
    Hawthorn Extract is a hawthorn extract, and its components include: Vitexin-2-O-rhamnoside. Hawthorn Extract is an orally active, anti-chronic heart failure protector that can improve exercise tolerance and reduce heart rate..
    Hawthorn Extract
  • HY-N13380
    6′‐O‐Galloylsalidroside 83013-86-9 98%
    6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases.
    6′‐O‐Galloylsalidroside
  • HY-N1353R
    Rhamnocitrin (Standard) 569-92-6
    Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells).
    Rhamnocitrin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity